According to Lipinski's Rule of Five, an orally active drug should fulfill at least how many of the listed criteria?

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Multiple Choice

According to Lipinski's Rule of Five, an orally active drug should fulfill at least how many of the listed criteria?

Explanation:
Lipinski's Rule of Five is a guideline for oral bioavailability. It says a drug-like molecule tends to be orally active if it satisfies no more than one violation among four criteria: molecular weight ≤ 500 Da, logP ≤ 5, hydrogen bond donors ≤ 5, and hydrogen bond acceptors ≤ 10. Since one violation is tolerable, you should meet at least three of the four criteria to have a good chance of oral absorption. That means the minimum number of criteria fulfilled is three, which is why the correct answer is three. Remember, this is a helpful rule of thumb, not an absolute rule—there are exceptions.

Lipinski's Rule of Five is a guideline for oral bioavailability. It says a drug-like molecule tends to be orally active if it satisfies no more than one violation among four criteria: molecular weight ≤ 500 Da, logP ≤ 5, hydrogen bond donors ≤ 5, and hydrogen bond acceptors ≤ 10. Since one violation is tolerable, you should meet at least three of the four criteria to have a good chance of oral absorption. That means the minimum number of criteria fulfilled is three, which is why the correct answer is three. Remember, this is a helpful rule of thumb, not an absolute rule—there are exceptions.

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