What enzyme resynthesizes acetylcholine?

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Multiple Choice

What enzyme resynthesizes acetylcholine?

Explanation:
Synthesis of acetylcholine in cholinergic neurons is driven by choline acetyltransferase, which transfers an acetyl group from acetyl-CoA to choline to form acetylcholine in the presynaptic terminal. After release, acetylcholine is quickly hydrolyzed by acetylcholinesterase in the synaptic cleft, and the choline is reabsorbed and reused by the same enzyme to make more acetylcholine. So the enzyme that resynthesizes acetylcholine is choline acetyltransferase. The other enzymes don’t resynthesize ACh: acetylcholinesterase breaks it down, monoamine oxidase acts on monoamines (like dopamine or serotonin), and tyrosine hydroxylase is involved in catecholamine synthesis.

Synthesis of acetylcholine in cholinergic neurons is driven by choline acetyltransferase, which transfers an acetyl group from acetyl-CoA to choline to form acetylcholine in the presynaptic terminal. After release, acetylcholine is quickly hydrolyzed by acetylcholinesterase in the synaptic cleft, and the choline is reabsorbed and reused by the same enzyme to make more acetylcholine. So the enzyme that resynthesizes acetylcholine is choline acetyltransferase. The other enzymes don’t resynthesize ACh: acetylcholinesterase breaks it down, monoamine oxidase acts on monoamines (like dopamine or serotonin), and tyrosine hydroxylase is involved in catecholamine synthesis.

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