Which muscarinic receptor subtype is associated with increased salivary gland secretion?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the Drug Action 2 Exam. Focus on multiple-choice questions, learn through interactive quizzes, and understand core drug mechanisms with explanations. Dive deep into pharmacokinetics and pharmacodynamics to ace your test!

Multiple Choice

Which muscarinic receptor subtype is associated with increased salivary gland secretion?

Explanation:
Muscarinic receptor subtype that drives salivary secretion is M3. When acetylcholine from parasympathetic nerves binds to M3 on salivary gland cells, it activates a Gq protein, which stimulates phospholipase C. This leads to production of IP3 and DAG; IP3 increases intracellular calcium, and the rise in calcium triggers exocytosis of saliva and promotes fluid secretion. M3 activity also supports ductal ion transport that shapes saliva. Other muscarinic subtypes have different tissue distributions and signaling: M1 is mainly neuronal and gland-related in some contexts, M2 is primarily in the heart and acts to lower cAMP via Gi, and M4 is also centered in the CNS. Thus, M3 is the receptor most closely linked to increased salivary secretion.

Muscarinic receptor subtype that drives salivary secretion is M3. When acetylcholine from parasympathetic nerves binds to M3 on salivary gland cells, it activates a Gq protein, which stimulates phospholipase C. This leads to production of IP3 and DAG; IP3 increases intracellular calcium, and the rise in calcium triggers exocytosis of saliva and promotes fluid secretion. M3 activity also supports ductal ion transport that shapes saliva. Other muscarinic subtypes have different tissue distributions and signaling: M1 is mainly neuronal and gland-related in some contexts, M2 is primarily in the heart and acts to lower cAMP via Gi, and M4 is also centered in the CNS. Thus, M3 is the receptor most closely linked to increased salivary secretion.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy